One of the backend mailbox stores behind imap.ru.ac.za is seeing an abnormally high load at the moment, and data is being read/written faster than the disks can cope with. This backend store hosts primarily staff and postgraduate students; the problem does not affect the other backend (which contains mostly undergraduate students).
This will make accessing your mailbox very slow. Repeatedly polling your mailbox will compound the problem.
As a result of this, a large amount of mail has backed up, and attempts to deliver this are also compounding the problem.